Use of clear aligners for the treatment of dental malocclusion in individuals with Osteogenesis Imperfecta Types III and IV
About this Study
Misalignment of teeth may interfere with oral hygiene, gum health, jaw function, opening of the jaw, chewing, breathing, and speech. It can also affect the shape of your face, mouth and overall quality of life. There is very little information on the appropriate treatment for teeth misalignment in OI.
The purpose of this study is to determine if it is safe to use Invisalign clear aligners in correcting the misalignment of teeth in people with OI. Clear aligners are transparent plastic trays that are designed to fit over your teeth. With each new tray, teeth are moved a little at a time until they reach the desired position. We plan to have approximately 57 people take part in this study.
If you take part in this study, you will be asked to come to a participating site for up to a total of 15 study visits over a course of 2 years and 4 months (or 28 months). People that agree to be in the study will have the following tests done at the study visits:
You may be eligible to participate if you:
- are between ages 12 – 40
- have OI type III or IV
- have had no prior orthodontic treatment
How to participate:
We greatly appreciate your interest in this study and in advancing the understanding of Osteogenesis Imperfecta.
In order to participate, you must contact the study coordinator of any of the participating institutions by phone or by e-mail. Please use the information below to inquire about participation.
Principal Investigator: Janice S. Lee
Address: 10 Center Dr, Room 5-2531, MSC 1470
Bethesda, MD 20892-1470
Sub-Investigators: Priyam Jani, Konstantinia Almpani
University of Missouri Kansas City
Principal Investigator: Jean-Marc Retrouvey
Address: University of Missouri Kansas City
25E St, Kansas City 64108
Principal Investigator: Deborah Krakow
Address: 615 Charles E. Young Dr. South Rm 410
Los Angeles, CA 90095-7358
Sub-Investigator: Eric Sung
Please Note: The Rare Diseases Clinical Research Network will make every effort to enroll all the patients we can, but we cannot make any guarantees that we will be able to enroll everyone in a particular study who wants to participate.