Northwestern University Feinberg School of Medicine

Chicago, Illinois

About the Center

The Northwestern University Feinberg School of Medicine CEGIR sites include the Divisions of Gastroenterology and Allergy/Immunology at Northwestern Medicine and Division of Pediatric Gastroenterology at the Anne and Robert Lurie Children’s Hospital of Chicago.

Northwestern Medicine-Northwestern Eosinophilic Digestive Disorders Program
The Northwestern Eosinophilic Digestive Disease Program (NEDD) cares for one of the largest adult cohorts in the world. The NEDD program has a dedicated clinical research team with expertise and NIH supported investigative interest in eosinophilic gastrointestinal diseases. The NEDD program is highly experienced with clinical trials in eosinophilic disorders as it served as a site for several major trials, including elimination diet, fluticasone, biologic therapies and oral viscous budesonide for EoE.

Northwestern has a long-standing and productive history of research in eosinophilic esophagitis and gastroenteritis. Pertinent to the CEGIR grant, our NEDD program was the first to demonstrate the effectiveness of the elimination diet therapy for adults with eosinophilic esophagitis. We have also developed and validated quality of life and endoscopic classification/grading instruments that are fundamental to the endpoints of the disease activity assessment.

The NEDD program has a long-standing and productive history of clinical, investigative and educational collaboration with the other CEGIR members regarding eosinophilic gastrointestinal diseases. The adult investigators at Northwestern Memorial Hospital have worked closely with pediatric investigators at Lurie Children’s Hospital to identify diagnostic criteria and establish empiric elimination diet as a frontline therapy for eosinophilic esophagitis. Our work with colleagues from Switzerland has demonstrated the effectiveness and safety of esophageal dilation in the management of eosinophilic esophagitis as well as validation of a multidimensional activity index for the disease. Our collaboration with investigators at the University of Illinois and University of Colorado has furthered development of minimally invasive, office-based testing for both children and adults with eosinophilic esophagitis. We are committed to furthering the understanding and study of eosinophilic gastrointestinal diseases.

Northwestern Memorial Hospital
Northwestern Medicine is one of Chicago's premier, multi-specialty physician organizations and is the regionally and nationally recognized physician group at the Feinberg School of Medicine of Northwestern University. Northwestern Memorial Hospital is one of the country’s premier academic medical center hospitals and a major referral center for the Midwest and beyond. Northwestern Memorial provides a total of 894 licensed beds in the Feinberg Pavilion, Prentice Women’s Hospital and the Stone Institute of Psychiatry. It is the primary teaching hospital for Northwestern University’s Feinberg School of Medicine and virtually every medical specialty is represented by the medical staff of 1,603 affiliated physicians who also carry appointments with the Feinberg School. Northwestern Memorial staffs 7,144 employees. Northwestern Memorial ranks 6th in U.S. News' 2013 Honor Roll.

The Division of Gastroenterology consists of 24 full-time faculty members, 10 fellows, and more than 35 staff members. The Gastroenterology outpatient practices offer patients more than 18,000 office visits and approximately 12,000 procedures annually. Drs. Hirano and Dr. Gonsalves have an extensive clinical exposure to patients with EoE and esophageal disorders. Dr. Hirano is the Director of the Esophageal Center at Northwestern University, which has access to over 1200 referrals annually. NIH funded members of the Esophageal Center include Dr. John Pandolfino, the Gastroenterology division chief, Dr. Peter Kahrilas, an internationally recognized figure in esophageal pathophysiology and Dr. Laurie Keefer, an authority on psychological aspects of gastrointestinal disorders. The reputation of the Esophageal Center attracts clinical and research trainees from around the world. Faculty of the esophageal center have been key authors of many of the guidelines on the major esophageal disorders including esophageal motility disorders, gastroesophageal reflux disease and eosinophilic esophagitis.

Ann & Robert H. Lurie Children’s Hospital of Chicago (formerly Children’s Memorial Hospital) is a new state-of-the-art tertiary care facility with a multi-building campus that provides care at 13 Chicago-area locations primarily serving children across Illinois and those from 49 states and 34 countries. Lurie Children’s has 1,100 pediatric specialists focusing on more than 70 specialties and cares for more children than any other pediatric hospital or system in Illinois.

The Division of Gastroenterology, Hepatology & Nutrition comprises 22 physicians (gastroenterologists/hepatologists/trainees), 6 pediatric nurse practitioners (APN), 8 nurses (RN), 3 registered dietitians (RD) in addition to research and administrative staff. Each year the Division has more than 8,800 patient visits and performs approximately 1,600 procedures.

The Eosinophilic Gastrointestinal Diseases (EGID) Program takes a multi-disciplinary approach and patients have access to pediatric gastroenterologists, a pediatric allergist, pediatric nurse clinicians, and a pediatric registered dietitian during a visit. The EGID program has substantial ongoing experience with several funded investigator initiated and multi-center studies including participation in clinical trials and collaborations with other institutions to advance basic and clinical research in this area.

Northwestern University Feinberg School of Medicine main website
Northwestern Medicine Gastroenterology Division website

Center Personnel

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