5906. Cross-sectional study defining the genetic bases of non-cystic fibrosis suppurative lung diseases and bronchiectasis, focusing on primary ciliary dyskinesia and primary immunodeficiencies

Status: Recruiting


A collaboration between pulmonologists and immunologists across the consortium, the project will systematically characterize the clinical phenotype and laboratory profile of patients with chronic suppurative respiratory diseases that are typically referred to pediatric and adult pulmonologists. A primary goal of this project is to identify the genetic basis of suppurative respiratory disease, including those with primary ciliary dyskinesia, primary immunodeficiencies, and other genetic disorders that interfere with airway defenses in patients without a confirmed genetic cause for their disease.

Participating Sites

University of North Carolina at Chapel Hill, Washington University in St. Louis (St. Louis, Missouri), University of Washington (Seattle, Washington), University of Colorado (Denver, Colorado), Stanford University (Palo Alto, California), The Hospital for Sick Children (Toronto, Ontario), McGill University (Montreal, Quebec) National Heart, Lung and Blood Institute (Bethesda, Maryland)