Contact Information:
Links:
www.ncia.nl (German)
www.n4i.nl (English)
www.radboudumc.nl/Research/
- Ter Haar N, Lachmann H, Ozen S, Woo P, Uziel Y, Modesto C, Koné-Paut I, Cantarini L, Insalaco A, Neven B, Hofer M, Rigante D, Al-Mayouf S, Touitou I, Gallizzi R, Papadopoulou-Alataki E, Martino S, Kuemmerle-Deschner J, Obici L, Iagaru N, Simon A, Nielsen S, Martini A, Ruperto N, Gattorno M, Frenkel J; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Eurofever/Eurotraps Projects". Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis 2012, Jun 29
- De Koning HD, Simon A, Zeeuwen PL, Schalkwijk J. Pattern recognition receptors in infectious skin diseases. Microbes Infect 2012; epub.
- de Koning HD, Simon A, Zeeuwen PL, Schalkwijk J. Pattern Recognition Receptors in Immune Disorders Affecting the Skin. J Innate Immun 2012; 4:225-240.
- Natasa Toplak, Joost Frenkel, Seza Ozen, Helen J Lachmann, Patricia Woo, Isabelle Koné-Paut, Fabrizio De Benedetti, Benedicte Neven, Michael Hofer, Pavla Dolezalova, Jasmin Kümmerle-Deschner, Isabelle Touitou, Veronique Hentgen, Anna Simon, Herman Girschick, Carlos Rose, Carine Wouters, Richard Vesely, Juan Arostegui, Silvia Stojanov, Huri Ozgodan, Alberto Martini, Nicolino Ruperto, Marco Gattorno. An International registry on Autoinflammatory diseases: the Eurofever experience. Ann Rheum Dis 2012; 71:1177-1182.
- N Toplak, J Frenkel, S Ozen, F De Benedetti, M Hofer, I Kone-Paut, H Girschick, B Neven, H Ozdogan, J Kummerle-Deschner, J Arostegui, A Simon, S Stojanov, R Vesely, C Wouters, V Hentgen, C Rose, P Dolezalova, H Lachmann, P Woo, I Touitou, A Martini, N Ruperto, M Gattorno. The Eurofever Registry for autoinflammatory diseases: results of the first 15 months of enrolment. Pediatric Rheumatology 2011; 9:1-1.
- Weegerink NJD, Schraders M, Leijendeckers J, Slieker K, Huygen PLM, Hoefsloot L, Oostrik J, Pennings RJE, Simon A, Snik A, Kremer H, Kunst HPM. Audiometric characteristics of a Dutch family with Muckle-Wells syndrome. Hearing Research 2011; 282:243-251.
- Bodar EJ, Kuijk L, Drenth JPH, Van der Meer JWM, Simon A*, Frenkel J*. On demand anakinra treatment is effective in mevalonate kinase deficiency. Ann Rheum Dis 2011; 70:1168-70.
- Stoffels M, Simon A. Hyper-IgD syndrome or mevalonate kinase deficiency. Curr Opin Rheumatol 2011; 23:419-23
- De Koning HD, Schalkwijk J, Van der Meer JWM, Simon A. Successful Canakinumab Treatment Identifies Interleukin-1 beta as a Pivotal Mediator in Schnitzler Syndrome. J Allergy Clin Immunol 2011, 2011;128:1352-4.
- Schellevis MA, Stoffels M, Hoppenreijs EP, Bodar E, Simon A, van der Meer JW. Variable expression and treatment of PAPA syndrome. Ann Rheum Dis 2011; 70:1168-70.
- Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011; 208:519-33.
- Bodar EJ, Simon A, Van der Meer JW. Effects of the histone deacetylase inhibitor ITF2357 in autoinflammatory syndromes. Mol Med 2011; 17:363-8.
- Piram M, Frenkel J, Gattorno M, Ozen S, Lachmann HJ, Goldbach-Mansky R, Hentgen V, Neven B, Stojanovic KS, Simon A, Kuemmerle-Deschner J, Hoffman H, Stojanov S, Duquesne A, Pillet P, Martini A, Pouchot J, Koné-Paut I; EUROFEVER and EUROTRAPS networks. A preliminary score for the assessment of disease activity in hereditary recurrent fevers: results from the AIDAI (Auto-Inflammatory Diseases Activity Index) Consensus Conference. Ann Rheum Dis. 2011 Feb;70(2):309-14.
- Simon A , Park H, Maddipati R, Bulua A, Jackson AJ, Chae JJ, Ettinger R, de Koning HD, Lobito AA, Kastner DL, Komarow H, Siegel RM. Concerted Action of Wild-type and Mutant TNF Receptors Enhances Inflammation in TNFR1-Associated Periodic Fever Syndrome (TRAPS). Proc Natl Acad Sci U S A. 2010 May 25;107(21):9801-6.
- Netea MG, Simon A, Van de Veerdonk F, Kullberg BJ, Van der Meer JWM, Joosten LAB. IL-1β Processing in Host Defense: Beyond the Inflammasomes. PLOS Pathogens 2010;6:2.
- Bodar EJ, Simon A, de Visser M, van der Meer JW. Complete remission of severe idiopathic cold urticaria on interleukin-1 receptor antagonist (anakinra). Neth J Med 2009, 67:302-5.
- De Wolff JF, Dickinson SJ, Molyneux K, Smith ACC, Feehally J, Simon A, Barratt J. Abnormal IgD and IgA1 O-glycosylation in Hyperimmunoglobulinaemia D and Periodic Fever Syndrome (HIDS). Clin Exp Medicine 2009; 9:291-96.
- Steichen O, van der Hilst J, Simon A, Cuisset L, Grateau G. A Clinical Criterion to Exclude the Hyperimmunoglobulin D Syndrome (Mild Mevalonate Kinase Deficiency) in Patients with Recurrent Fever. J Rheumatol 2009;36:1677-81.
- Van der Hilst JC, Kluve-Beckerman B, van der Meer JW, Simon A. Cathepsin D activity protects against development of type AA amyloid fibrils. Eur J Clin Invest. 2009;39:412-6.
- Hoffman HM, Simon A. Recurrent febrile syndromes – what does a rheumatologist need to know? Nat. Rev. Rheumatol. 2009; 5: 249–256.
- Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror Autoinflammaticus: the molecular pathophysiology of Autoinflammatory Disease. Annu. Rev. Immunol. 2009; 27:621–668.
- Van der Hilst JC, Bodar EJ, Barron KS, Frenkel J, Drenth JP, van der Meer JW, Simon A; the International HIDS Study Group. Long-Term Follow-Up, Clinical Features, and Quality of Life in a Series of 103 Patients With Hyperimmunoglobulinemia D Syndrome. Medicine (Baltimore). 2008; 87:301-310.
- Bodar EJ, Drenth JPH, Van der Meer JWM, Simon A. Dysregulation of innate immunity: hereditary periodic fever syndromes. Brit J Haematol 2008; 144: 279-302.
- Van der Hilst JC, Yamada T, Op den Camp HJ, van der Meer JW, Drenth JP, Simon A. Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis. Rheumatology (Oxford). 2008; 47:1651-4.
- Van der Hilst JCH, Kluve-Beckerman B, Bodar EJ, Van der Meer JWM, Drenth JPH, Simon A. Lovastatin inhibits formation of AA amyloid. J Leuk Biol 2008; 83:1295-9.
- Simon A , Kullberg BJ, Boerman OC, Van der Ven J, Tripet B, Zeeuwen P, Verweij P, Schalkwijk J, Hodges R, Van der Meer JWM, Netea MG. Drosomycin-like defensin (DLD): a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob. Agents Chemother. 2008; 52:1407-12.
- Ryan JG, de Koning HD, Beck LA, Booty MG, Kastner DL, Simon A. IL-1 blockade in Schnitzler syndrome: Ex vivo findings correlate with clinical remission. J Allergy Clin Immunol 2008; 121:260-2.
- De Koning HD, Bodar EJ, Van der Meer JWM, Simon A. Schnitzler syndrome: beyond the case reports. Review and follow-up of 94 patients with an emphasis on prognosis and treatment. Semin Arthritis Rheum. 2007 Dec;37(3):137-48.
- Van der Hilst JC, Van der Meer JWM, Drenth JPH, Simon A. AL amyloidosis enhances development of AA amyloidosis. Br J Dermatol. 2007 Apr;156(4):748-9.
- Bodar EJ, Van der Hilst JCH, Van Heerde W, Van der Meer JWM, Drenth JPH, Simon A. Defective apoptosis of peripheral blood lymphocytes in hyper-IgD and periodic fever syndrome. Blood 2007; 109:2416-8
- Simon A , Van der Meer JWM. Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes. Am J Physiol Regul Integr Comp Physiol. 2007; 292:R86-98.
- Simon A , Van der Meer JWM, Veselý R, Myrdal U, Yoshimura K, Duys P, Drenth JPH & contributing members of the International HIDS Study Group. Approach to genetic analysis in diagnosis of hereditary autoinflammatory syndromes. Rheumatology 2006; 45:269-73.
- De Koning HD, Bodar EJ, Simon A, Van der Hilst JCH, Netea MG, Van der Meer JWM. Beneficial response to anakinra and thalidomide in Schnitzler’s syndrome. Ann Rheum Dis 2006; 65:542-4.
- Bodar EJ, Van der Hilst JCH, Drenth JPH, Van der Meer JWM, Simon A. Effect of etanercept and anakinra on inflammatory attacks in the Hyper-IgD syndrome: introducing a vaccination provocation model. Neth J Med 2005; 63:260-4.
- van der Hilst JCH, Drenth JPH, Bodar EJ, Bijzet J, van der Meer JWM, Simon A and contributing members of the International HIDS Study Group. Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome. Amyloid 2005; 12:115-119 .
- Van der Hilst JCH, Simon A, Drenth JPH. Hereditary Periodic fever and reactive amyloidosis. Clin Exp Med 2005; 5:87-98.
- Simon A, Van der Meer JWM, Drenth JPH. Familial Mediterranean Fever – a not so unusual cause of abdominal pain. Best Pract Res Cl Ga 2005; 19:199-213
- Simon A , Bodar EJ, Fiselier TJW, Cuppen MPJM, Van der Hilst JCH, Drenth JPH, van der Meer JWM. Beneficial response to interleukin-1-receptor antagonist in a patient with severe, treatment-resistant TNF-receptor associated periodic syndrome (TRAPS). Am J Med 2004; 117:208-10.
- Simon A, Bijzet J, Voorbij HAM, Mantovani A, Van der Meer JWM, Drenth JPH. Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response. J Intern Med 2004; 256:247-53.
- Simon A , Drewe E, van der Meer JWM, Powell RJ, Kelley RI, Stalenhoef AFH, Drenth JPH. Simvastatin treatment for inflammatory attacks of the hyper-IgD and periodic fever syndrome. Clin Pharm Therap2004; 75: 476-83.
- Simon A , Kremer HPH, Wevers RA, Scheffer H, de Jong JG, van der Meer JWM, Drenth JPH. Mevalonate kinase deficiency: evidence for a phenotypic continuum. Neurology 2004; 62:994-7.
- Simon A , Mariman EC, Van der Meer JWM, Drenth JPH. Major mutation of the hyper-IgD and periodic fever syndrome originates from one common ancestor – truly Dutch type periodic fever? Am J Med 2003; 114:148-52.
- Simon A , Van Deuren M, Tighe PJ, Van der Meer JWM, Drenth JPH. Genetic analysis: valuable key to diagnosis and treatment in periodic fever. Arch Intern Med 2001; 161:2491-3.
- Simon A , Cuisset L, Vincent MF, Van der Velde-Visser SD, Delpech M, Van der Meer JWM, Drenth JPH, International HIDS Study Group. Molecular analysis of the mevalonate kinase gene in a cohort of patients with the hyper-IgD and periodic fever syndrome: its application as a diagnostic tool. Ann Intern Med 2001; 135:338-43.
- Drenth JPH, Vonk AG, Simon A, Powell R, Van der Meer JWM. Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. J Pharm Exp Ther 2001; 298:1221-6.
- Cuisset L, Drenth JPH, Simon A, Vincent MF, Van der Velde-Visser S, Van der Meer JWM, Grateau G, Delpech M, International Hyper-IgD Study Group. Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome. Eur J Hum Genet 2001; 9:260-6.
- Simon A , Dodé C, van der Meer JWM, Drenth JPH. Familial periodic fever and amyloidosis due to a new mutation in the TNFRSF1A gene. Am J Med 2001; 110:313-6.
- Simon A , Van der Meer JWM, Drenth JPH. Chapter 114 Familial auto-inflammatory syndromes. (revised edition) In: Harris ED et al, eds. Kelley’s Textbook of Rheumatology. 8th ed. Saunders. 2009, 7th ed 2004.
- Bodar EJ, Simon A, Drenth JPH. Chapter 67 - Hereditary periodic fever syndromes. In: Shah SS, ed. Pediatric Practice: Infectious Diseases. 1st ed. McGraw-Hill, 2009: 637-648.